Tag Archives: Disease

Renal Iron Handling In Health and Disease

Invitation to submit research and review articles related to Renal Iron Handling in Health and Disease.

While iron is a pre-requisite for life, it also initiates a cascade of pathological events that lead to parenchymal damage and activation of immune cells. Iron-dependent regulated cell death, namely ferroptosis, potentiates kidney injury and ironically, delivery of iron (or iron-loaded macrophages) to the kidney reduces the severity of the disease. Clearly, this represents our incomplete understanding iron metabolism in kidney health and pathology.


              We invite investigators to contribute original research articles as well as review articles that will aid in the understanding of iron metabolism and trafficking in the initiation and outcomes of kidney injury and chronic kidney disease.

Potential topics include, but are not limited to:

• Characterization and determination of the role of the kidney in iron trafficking and metabolism
• Effects of disorders of systemic iron metabolism (e.g. iron deficiency and iron overload) on the kidney, including new techniques to measure iron content (free or protein-bound) in tissue, plasma and cells
– Iron homeostasis in kidney disease (proteinuria, glomerulopathy and chronic kidney disease)
• Mechanism of iron-mediated kidney injury;
• Modulation of iron and hepcidin levels as therapeutic strategies to overcome injury and/or promote recovery 


Please use the following link to access the submission page

https://www.frontiersin.org/research-topics/11684/renal-iron-handling-in-health-and-disease

Controversies Conference on Optimal Anemia Management in Chronic Kidney Disease

Dear BioIron community,

We are seeking your input into an upcoming Controversies Conference on Optimal Anemia Management in Chronic Kidney Disease that is being organized by KDIGO (Kidney Disease: Improving Global Outcomes), an international organization whose mission is to improve the care and outcomes of kidney disease patients worldwide:

Anemia and disordered iron homeostasis are prevalent in patients with chronic kidney disease (CKD) and associated with significant adverse consequences. As such, in December 2019 KDIGO will gather together a global panel of multidisciplinary clinical and scientific expertise to identify key issues relevant to the optimal management of anemia in CKD.

The KDIGO Optimal Anemia Management in CKD Conference will focus largely on iron, including the contribution of iron pathophysiology to the anemia of CKD and adverse patient outcomes, iron therapeutic agents, and the impact of other current and emerging anemia therapies on hemoglobin targets, iron parameters, and iron supplementation needs. The goal of this KDIGO conference is to determine best practice and areas of uncertainties in the treatment of anemia, review key relevant literature published since the 2012 KDIGO Anemia Guideline, identify new topics or issues to be revisited for the next iteration of the KDIGO guideline, and outline research needed to improve anemia management in CKD.

Drs. Tilman B. Drüeke (INSERM U-1018, Hôpital Paul Brousse, Villejuif, France) and Jodie L. Babitt (Massachusetts General Hospital, Boston, MA, USA) will co-chair this conference.

KDIGO makes preliminary Scope of Work documents available for public review prior to final planning of any Controversies Conference. To this end, we cordially invite your input on the Optimal Anemia Management Conference Scope of Work which can be found at the following website: 

Controversies Conference on Optimal Anemia Management in CKD – kdigo.orgThe objective of the KDIGO Controversies Conference on Optimal Anemia Management in CKD is to gather a global panel of multidisciplinary clinical and scientific expertise to identify key issues relevant to the optimal management of anemia in CKD.kdigo.org

We are seeking a broad range of feedback, including from basic scientists and clinicians outside of nephrology who have expertise in iron/anemia. Kindly submit your comments via the feedback form on the website no later than Monday, November 11th.

Best,

Jodie

Jodie L. Babitt, M.D.
Associate Professor of Medicine
Harvard Medical School

MGH Research Scholar

Director of Translational Research

Nephrology Division
Massachusetts General Hospital
185 Cambridge St., CPZN 8208
Boston, MA 02114
tel. 617-643-3181
fax 617-643-3182
Babitt.Jodie@mgh.harvard.edu