The Bioiron community proudly salutes IBIS veteran member and distinguished scientist and clinician Hossein Ardehali, MD, PhD, Professor of Professor of Medicine – Cardiology and Pharmacology on his election as President of the American Society for Clinical Investigation (ASCI). We wish him success in his new post as in all his scientific endeavors that, as we know, are intimately related to iron in health and disease.
Ioav Cabantchik. President of the Bioiron Society. Posted April 25, 2019
Michela Asperti, PhD
Podium 27
FERROPTOSIS: A NEW POTENTIAL THERAPEUTIC TARGET FOR AGGRESSIVE TUMORS. A PRELIMINARY STUDY ON HELA, HEPG2 AND RHABDOMYOSARCOMA CELL LINES
Deborah Stefanova
Podium 20
HEPCIDIN MEDIATES HOST DEFENSE AGAINST GRAM-NEGATIVE PATHOGENS BY CONTROLLING NON-TRANSFERRIN-BOUND IRON
Antonella Nai, PhD
Podium 33
TFR2: A NOVEL POTENTIAL THERAPEUTIC TARGET FOR Β -THALASSEMIA
Veena Sangkhae, PhD
Podium 39
EFFECTS OF MATERNAL IRON STATUS ON PLACENTAL IRON TRANSFER
Anthony Grillo, PhD
Podium 52
RESTORED IRON TRANSPORT BY A SMALL MOLECULE PROMOTES GUT IRON ABSORPTION AND HEMOGLOBINIZATION IN MICE, RATS, AND ZEBRAFISH
Susanna Canali
Podium 51
ACTIVIN B UTILIZES ACTIVIN TYPE II RECEPTORS, BMP TYPE I RECEPTORS, HEMOJUVELIN AND SMAD1/5/8 SELECTIVELY IN HEPATOCYTES TO PROMOTE HEPCIDIN INDUCTION BY INFLAMMATION IN MICE
Milene Costa de Silva
Podium 19
IRON LEVELS DEFINE TWO POPULATIONS OF TUMOR ASSOCIATED MACROPHAGES
Debora Stefanova
Podium 46
THE ROLE OF IRON AND HEPCIDIN IN YERSINIA ENTEROCOLITICA INFECTION
Francesca Vinchi
Podium 42
HEME AND IRON CONTROL OF MACROPHAGE PLASTICITY IS PREVENTED BY THE HEME SCAVENGER HEMOPEXIN AND THE IRON CHELATOR DFO
Brie Fuqua , University of California , Berkeley, CA, USA
Podium 24
SEVERE DEFECTS IN IRON METABOLISM IN MICE WITH DOUBLE KNOCKOUT OF THE MULTICOPPER FERROXIDASES HEPHAESTIN AND CERULOPLASMINBrie Fuqua (Presenter), Deepak Darshan, David Frazer, Sarah Wilkins, Chris Vulpe and Gregory Anderson (University of California, Berkeley, CA, USA, and the Queensland Institute of Medical Research, Brisbane, Australia)
Claire Mayeur , Massachusetts General Hospital , Boston, MA, USA
Podium 40
IN A MOUSE MODEL OF CHRONIC INFLMATION, LIVER-SPECIFIC DELETION OF ALK3 (A BMP TYPE I RECEPTOR) PREVENTS THE DEVELOENT OF ANEMIA OF INFLMATIONClaire Mayeur, MD (Presenter), Andrea S. Steinbicker, MD (Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany), Starsha A. Kolodziej and Kenneth D. Bloch, MD
Léon Kautz , University of California Los Angeles, Center for Iron Disorders , Los Angeles, CA, USA
Podium 30
THE ERYTHROID FACTOR ERYTHROFERRONE AND ITS ROLE IN IRON HOMEOSTASISLéon Kautz, PhD (Presenter), Elizabeta Nemeth, PhD and Tomas Ganz, PhD, MD
Sandro Altamura , Molecular Medicine Partnership Unit , Heidelberg, Germancy
Podium 7
IN VIVO DISRUPTION OF THE HEPCIDIN-FERROPORTIN REGULATORY CIRCUITRY CAUSES FATAL SYSTEMIC AND EXOCRINE PANCREATIC IRON OVERLOADSandro Altamura (Presenter), Hermann-Josef Groene (Deutsches Krebsforschungszentrum, Heidelberg), Regina Kessler (MMPU), Bruno Galy (European Molecular Biology Laboratory, Heidelberg), Matthias Hentze (MMPU, EMBL) and Martina Muckenthaler (MMPU)
Raffaella Gozzelino , Instituto Gulbenkian de Ciência , Oeiras, Portugal
Podium 2
METABOLIC ADAPTATION TO TISSUE IRON OVERLOAD CONFERS TOLERANCE TO MALARIARaffaella Gozzelino, PhD (Presenter), Bruno Bezerril Andrade (2), Rasmus Larsen (3), Nivea F. Luz (4), Liviu Vanoaica (5), Antonio Coutinho (3), Silvia Cardoso (3), Sofia Rebelo (3), Maura Poli (6), Manoel Barral-Netto (7), Deepak Darshan (5), Lukas Kühn (5) and Miguel P. Soares (3)
(2) Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
(3) Inflammation Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal
(4) Centro de Pesquisas Gonçalo Moniz, undação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil
(5) Ecole Polytechnique Fédérale de Lausanne (EPFL), Swiss Institute for Experimental Cancer Research (ISREC), Switzerland
(6) Dipartimento Materno Infantile e Tecnologie Biomediche, University of Brescia, Italy
(7) Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Bahia, Brazil
Sara Petrillo
Poster 8
HEME ACCUMULATION IN ENDOTHELIAL CELLS IMPAIRS ANGIOGENESIS BY TRIGGERING PARAPTOSIS
Ki Soon Kim
Poster 6
RECOVERY OF HEME OXYGENASE 1-DEFICIENT MICE THROUGH REPOPULATION OF WT MACROPHAGES IN RETICULOENDOTHEILAL SYSTEM
Supak Jenkitkasemwong, PhD
Poster 187
A NOVEL ROLE FOR ZIP8 IN ERYTHROPOIESIS
Lisa Traeger
Poster 207
HOMOMERIC AND HETEROMERIC RECEPTOR COMPLEX FORMATION OF BONE MORPHOGENETIC TYPE I RECEPTORS ALK2 AND ALK3
Ritama Gupta
Poster 25
ELUCIDATING THE ROLE OF IL6 AND REACTIVE OXYGEN SPECIES (ROS) IN BONE MARROW ERYTHROPOIESIS AND IN THE DEVELOPMENT OF ANEMIA UNDER INFLAMMATORY CONDITIONS
Wei Zhang
Poster 149
THE METAL-ION TRANSPORTER ZIP8 (SLC39A8) AND IRON TRANSPORT ACROSS THE PLACENTA
Ana Rita da Silva
Poster 43
INVESTIGATION OF LINKS BETWEEN HEPCIDIN TRANSCRIPTIONAL CONTROL AND CELLULAR ENERGY STATUS
Joana Neves
Poster 42
DISRUPTION OF THE HEPCIDIN/FERROPORTIN REGULATORY CIRCUITRY CAUSES INCREASED PULMONARY IRON CONTENT AND RESTRICTIVE LUNG DISEASE
Jithu James
Poster 85
INSULIN SIGNALLING IS IMPAIRED IN IRON-LOADED PRIMARY HEPATOCYTES
Nicole Wilkinson , Lady Davis Institute for Medical Research and McGill University , Montreal, QC, Canada
Poster 32
DEFECTIVE GLUCOSE METABOLISM IN IRP1-/- MICENicole Wilkinson (Presenter) and Kostas Pantopoulos, PhD (McGill University)
Sonia Mercurio , University of Turin , Turin, Italy
Poster 174
DISTINCT ROLES OF FLVCR1 ISOFORMS IN PRIMITIVE AND DEFINITIVE ERYTHROPOIESISSonia Mercurio (Presenter), Sara Petrillo, PhD Student, Chiabrando Deborah, PhD, Giulio Valperga, Student, Lorenzo Silengo, Prof., Fiorella Altruda, Prof., Massimo Santoro, Assistant Prof. and Emanuela Tolosano, Prof.
Department of Molecuar Biotechnology and Health Sciences and Molecular Biotechnology Center, University of Turin, Turin, Italy
Mariia Lunova , Universitätsklinikum Ulm , Ulm, Germany
Poster 318
HEPCIDIN KNOCKOUT MICE DEVELOP CHRONIC LIVER INJURY AND LIVER FIBROSIS AS A CONSEQUENCE OF LYSOSOMAL IRON OVERLOADMariia Lunova (Presenter), Katrin Muller, PhD student (2), Johannes Haybaeck, Dr (3), Sophie Vaulont, Prof. (4), Caroline Lackner, Prof. (3), Christian Trautwein, Prof. (5) and Pavel Strnad, PD, Dr (5)
(1) Uniklinik Ulm
(2) Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany
(3) Institute of Pathology, Medical University of Graz, Graz
(4) Institut Cochin, INSERM U1016, Université Paris Descartes, Paris, France
(5) Department of Medicine III, University Hospital Aachen, Aachen, Germany
Carla Casu , Weill Cornell Medical College , New York, NY
Poster 324
SUPPRESSION OF TMPRSS6 USING ANTISENSE TECHNOLOGY AMELIORATES HEREDITARY HEMOCHROMATOSIS AND BETA-THALASSEMIAC. Casu (1) (Presenter), S. Guo (2), S. Gardenghi, S. Booten, A. Watt, S. Freier, Y. Ginzburg, R. Fleming, B.P. Monia and S. Rivella
(1) Weill Cornell Medical College, New York, NY
(2) Isis Pharmaceuticals
Alan Chen , Duke University , Durham, NC
Poster 268
INACTIVATION OF TRANSFERRIN RECEPTOR (TFR1) IN THE PANCREAS RESULTS IN PANCREATITIS AND DIABETESAlan Chen (Presenter), Renee M. Ned, PhD (2), Adriana Donovan, PhD (3) and Nancy C. Andrews, MD, PhD (1)
(1) Duke University
(2) CDC
(3) Children’s Hospital
To honor the memory of Hiromi Gunshin, and that of Joanne Levy who died at young age after having done a pioneer works on iron homeostasis, the BioIron Board of Directors proposed to establish a Fund to grant two travel awards in the name of Hiromi Gunshin, and Joanne Levy to support young scientists to attend the BioIron meetings.
Deborah Chiabrando, PhD
Samira Lakhal-Littleton, PhD
Francesca Vinchi, PhD
Raffaela Gozzelino, PhD
Karin Finberg, MD, PhD
Laura Silvestri, PhD
Deborah Chiabrando
A NOVEL MITOCHONDRIAL ISOFORM OF THE HEME EXPORTER FLVCR1 INVOLVED IN HEME BIOSYNTHESIS
Deliang Zhang, PhD
HEPCIDIN REGULATES FERROPORTIN EXPRESSION AND INTERACELLULAR IRON CONCENTRATION OF ERYTHROBLASTS
Marcel Simon
Marcel Simon was Head of the Diabetology Unit and Dean of the Faculty of Medicine at Rennes University, France. Very proud of his Briton roots and endowed with a marked sense of humour, he got interested very early in hemochromatosis, as his MD thesis was entitled “Heredity of Idiopathic Hemochromatosis.” He soon became a pioneer in the genetics of hemochromatosis, in 1975 by showing the close linkage of the disease to the HLA system on chromosome 6, and in 1977 by demonstrating its recessive mode of inheritance. This opened the way to efficient family screenings. His premature death in 1988, aged 53, was a great loss for the Iron Field. It is to pay tribute to his major contributions and attractive personality that the Marcel Simon Prize was created, and is awarded for excellence in the research of genetic hemochromatosis, at the IBIS meeting every two years.
The Marcel Simon Award is funded by “The Margrit Krikker, M.D. Endowment Fund.”
Chaim Herschko, MD
John B. Porter, MA, MD, FRCP DRCPath
Ioav Cabantchik, MD, PhD
Pierre Brissot, MD
(for Lifetime Achievement)
Jerry Kaplan, PhD
(for Lifetime Achievement)
Jodie Babitt, MD
(for research regarding the role of BMP-6 in Iron Homeostasis)
Marie-Paule Roth, MD
(for research regarding the role of BMP-6 in Iron Homeostasis)
Nancy Andrews, MP, PhD
(for animal models of hemochromatosis)
Sophie Vaulont, MD, PhD
(for the discovery of hepcidin)
Tomas Ganz, MD, PhD
(for the discovery of hepcidin)
Oliver Loreal, MD, PhD
(for the discovery of hepcidin)
Clara Camaschella, MD
(for the study of non-HFE hemochromatosis)
Robert E. Fleming, MD
(for the study of HFE biology)
Jose A. Lebron, PhD
(for the characterization of HFE structure and interactions)
John N. Feder, PhD
(for the identification of HFE)
Antonello Pietrangelo, MD
(for the studies on the pathogenesis of hemochromatosis)
Wolfgang Stremmel, MD
(for the studies on protein for intestinal iron-uptake)
Lawrie Powell, MD, PhD
(for the studies on clinical aspects of Hemochromatosis)
June Halliday, PhD
(for the studies on clinical aspects of Hemochromatosis)
Bruce R. Bacon, MD
(for the studies on Iron toxicity)