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Synthesis and breakdown of universal metabolic precursors promoted by iron

Muchowska KB, Varma SJ, Moran J

Nature. 2019 May;569(7754):104-107. PDF

Recommended by Dr. Paolo Arosio


A possible non-biological reaction framework for metabolic processes on early Earth

Pascal R.

Nature. 2019 May;569(7754):47-49.PDF

In memory of Leo Richard Zacharski

It was with great sadness that we learned that Leo Richard Zacharski, MD, passed away on August 23, 2019 at the age of 81. 

Leo Richard Zacharski Leo attended Wayne State University and then received his MD degree in 1962 from Wayne State Medical School in Detroit. He served an internship at Harper Hospital in Detroit followed by a residency in internal medicine and subspecialty training in hematology at the Mayo Clinic in Rochester, Minnesota. He served as a Captain in the US Army Medical Corp from 1966 to 1968. He was appointed Assistant Professor of Medicine at Dartmouth Medical School and Staff Physician at the VA Hospital in White River Junction, Vermont in January 1970. He specialized in diagnosis and treatment of patients with bleeding and clotting disease, and also iron overload disease. While early motivations were toward medical missions, the heart of his career was devotion to biomedical research believing that he could best serve humanity through discovery and innovation. He was awarded Research Career Development positions at the VA hospital and became the Associate Chief of Staff for Research there in 1985, a position held until retirement from the VA in 2004. During his tenure with the VA he authored over 250 published papers and over 100 abstracts. He served as Chairman of three National VA Cooperative Studies. He achieved the rank of Professor of Medicine in 1985 and became Professor of Medicine Active Emeritus in 2013. Devotion to his “calling” prompted continuation of his research following retirement. His most productive years followed retirement during which he coined the term, “ferrotoxic disease”, referring to diseases of aging caused by oxidative stress due to progressive iron accumulation. He was a member of the American College of Physicians, American Society of Hematology, International Society on Thrombosis and Haemostasis, International BioIron Society and East-West Iron Club; and served on the Medical Advisory Board of the Iron Disorders Institute (irondisorders.org). His personal Christian faith prompted deep appreciation of the elegant intricacy and beauty of the “natural order” which was the basis for his devotion to biomedical research.

Xi Huang, Ph.D.

Founder and President


Postdoctoral Position at the Weizmann Institute

A Postdoctoral position to study Ferroptosis in cancer 

A three-years Postdoctoral position is available at the Weizmann Institute of Science to study the role of ferroptosis in breast cancer development and treatment

We employ multidisciplinary experimental approaches including advanced molecular cell biology methods, High Throughput drugs Screens, cell signaling and bioinformatics tools utilizing in vitro cellular models and in vivo animal models as well as cancer patient samples. 

We search for a highly motivated candidate with a background in cell signaling and  biochemistry. Individuals with experience with animal models are preferred

Applications with a CV and up to three contacts for references should be sent to:

Prof. Sima Lev

Department of Molecular Cell Biology, 

The Weizmann Institute of Science,

Rehovot 76100, Israel. 

Email:  sima.lev@weizmann.ac.il

Tel: 972-8-934-2126


Hossein Ardehali, MD, PhD named President of the American Society for Clinical Investigation (ASCI)

The Bioiron community proudly salutes IBIS veteran member and distinguished scientist and clinician Hossein Ardehali, MD, PhD, Professor of Professor of Medicine – Cardiology and Pharmacology on his election as President of the American Society for Clinical Investigation (ASCI). We wish him success in his new post as in all his scientific endeavors that, as we know, are intimately related to iron in health and disease.

Ioav Cabantchik. President of the Bioiron Society. Posted April 25, 2019

Renewable fellowship is immediately available in the Regulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute (Milan, Italy).


“A one-year renewable fellowship is immediately available in the Regulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute (Milan, Italy).

We search for a young motivated post-graduate fellow with a degree in Biology, Biotechnology or related disciplines interested in basic and translational research, who wish to advance in his/her academic training. The selected candidate will work on a project aimed at characterizing the role of the second transferrin receptor in mice models of different forms of anemia for the development of novel therapeutic approaches. Previous experience with in vivo models will be considered a plus. Salary will be commensurate with qualification and expertise.

Applications with a CV and up to two contacts for references should be sent to nai.antonella@hsr.it


Brittany Gyuricza

X5963; brittany@wjweiser.com