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Hot Off The Press

Synthesis and breakdown of universal metabolic precursors promoted by iron

Muchowska KB, Varma SJ, Moran J

Nature. 2019 May;569(7754):104-107. PDF

Recommended by Dr. Paolo Arosio


A possible non-biological reaction framework for metabolic processes on early Earth

Pascal R.

Nature. 2019 May;569(7754):47-49.PDF

Phylogenetic origin of hepcidin

Paolo sent me this comment/question, which I thought would be great to post to the forum.

“We had a number of very interesting reviews on the function, regulation and structure of the human and mouse hepcidin, even of the camel one, but we know very little of its phylogenetic origin. For example there is a large number of papers on fish hepcidin, mostly linked to inflammation, infection, but few, if any, regarding iron homeostasis.

Briefly, is it known when first occurred the encounter between hepcidin and ferroportin with the ensuing regulatory consequences?”


Well, iron community, does anyone have any thoughts on this?

In Memory of Barry Paw

In Memory of Barry Paw

IBIS, the BioIron Society joins the medical and scientific community in mourning the loss of one of its most prominent members, Barry Paw, MD-PhD.

It was with great sadness that we learned that our friend and colleague Barry Paw (age 56) passed away on Friday, December 27. Barry and his parents came to the United States from Burma in 1969, when he was seven years old. He commented on his emigration, a comment that’s probably worth repeating.

“Even with their education, it was like Nazi Germany, first comes loss of right to own property, then citizenship, then right to teach at a university the next year. It comes in increments so people keep hoping, perhaps next year would be better… Then it is too late to leave. By 1969, we waited 2 years for permission to leave which disqualified you from working for civil service, and we landed in US with US$ 30 per person and 1 suitcase of clothes per person. Whatever wealth we had was left behind. America gave us a real 2nd chance to build a new life.”

Barry Paw.Barry’s family lived in California and he was educated at California public schools and universities. He did his undergraduate work at University of California at Berkeley. As an undergraduate Barry published his first scientific papers with Joe Nielands on the synthesis of bacterial siderophores. Barry then did a MD/PhD in University of California Los Angeles with Elizabeth Neufeld. In a series of papers, with Barry as first author, they identified the molecular basis of adult and chronic Gm2 gangliosidosis (Tay-Sachs disease) a disease which is highly prevalent in Ashkenazi Jews.

Barry Paw.Barry then did his residency in Pediatric Hematology and Oncology at Boston Children’s Hospital, Harvard Medical School. Barry did a fellowship with Len Zon and was Len’s first fellow working on zebrafish. First with Len and then as an independent investigator Barry pioneered the use of zebrafish to study red cell development focusing on iron and heme metabolism. His work resulted in the identification of a number of genes involved in these processes. Barry’s studies pioneered the use of zebrafish for the analysis and study of genes responsible for human diseases.

Barry loved to collaborate and a list of co-authors on his papers include many in the field. But even beyond that — Barry was a mentor, as one of his former trainees said” I remember Barry as someone who was very aggressive about helping trainees promote their careers and very honest about what we needed to do to get there. I think the most outstanding contribution was getting technicians first author papers in top journals and they pretty much had their pick of what they wanted to do. Not many PIs will invest this much into people who are so junior.”

Barry Paw.Barry will rightfully be remembered for his scientific discoveries and the rigor and importance of his work. But he will also be remembered for his modesty, generosity, and most of all his sweetness of character.

Jerry Kaplan

posted: January 3, 2018