Category Archives: News

Renal Iron Handling In Health and Disease

Invitation to submit research and review articles related to Renal Iron Handling in Health and Disease.

While iron is a pre-requisite for life, it also initiates a cascade of pathological events that lead to parenchymal damage and activation of immune cells. Iron-dependent regulated cell death, namely ferroptosis, potentiates kidney injury and ironically, delivery of iron (or iron-loaded macrophages) to the kidney reduces the severity of the disease. Clearly, this represents our incomplete understanding iron metabolism in kidney health and pathology.


              We invite investigators to contribute original research articles as well as review articles that will aid in the understanding of iron metabolism and trafficking in the initiation and outcomes of kidney injury and chronic kidney disease.

Potential topics include, but are not limited to:

• Characterization and determination of the role of the kidney in iron trafficking and metabolism
• Effects of disorders of systemic iron metabolism (e.g. iron deficiency and iron overload) on the kidney, including new techniques to measure iron content (free or protein-bound) in tissue, plasma and cells
– Iron homeostasis in kidney disease (proteinuria, glomerulopathy and chronic kidney disease)
• Mechanism of iron-mediated kidney injury;
• Modulation of iron and hepcidin levels as therapeutic strategies to overcome injury and/or promote recovery 


Please use the following link to access the submission page

https://www.frontiersin.org/research-topics/11684/renal-iron-handling-in-health-and-disease

Controversies Conference on Optimal Anemia Management in Chronic Kidney Disease

Dear BioIron community,

We are seeking your input into an upcoming Controversies Conference on Optimal Anemia Management in Chronic Kidney Disease that is being organized by KDIGO (Kidney Disease: Improving Global Outcomes), an international organization whose mission is to improve the care and outcomes of kidney disease patients worldwide:

Anemia and disordered iron homeostasis are prevalent in patients with chronic kidney disease (CKD) and associated with significant adverse consequences. As such, in December 2019 KDIGO will gather together a global panel of multidisciplinary clinical and scientific expertise to identify key issues relevant to the optimal management of anemia in CKD.

The KDIGO Optimal Anemia Management in CKD Conference will focus largely on iron, including the contribution of iron pathophysiology to the anemia of CKD and adverse patient outcomes, iron therapeutic agents, and the impact of other current and emerging anemia therapies on hemoglobin targets, iron parameters, and iron supplementation needs. The goal of this KDIGO conference is to determine best practice and areas of uncertainties in the treatment of anemia, review key relevant literature published since the 2012 KDIGO Anemia Guideline, identify new topics or issues to be revisited for the next iteration of the KDIGO guideline, and outline research needed to improve anemia management in CKD.

Drs. Tilman B. Drüeke (INSERM U-1018, Hôpital Paul Brousse, Villejuif, France) and Jodie L. Babitt (Massachusetts General Hospital, Boston, MA, USA) will co-chair this conference.

KDIGO makes preliminary Scope of Work documents available for public review prior to final planning of any Controversies Conference. To this end, we cordially invite your input on the Optimal Anemia Management Conference Scope of Work which can be found at the following website: 

Controversies Conference on Optimal Anemia Management in CKD – kdigo.orgThe objective of the KDIGO Controversies Conference on Optimal Anemia Management in CKD is to gather a global panel of multidisciplinary clinical and scientific expertise to identify key issues relevant to the optimal management of anemia in CKD.kdigo.org

We are seeking a broad range of feedback, including from basic scientists and clinicians outside of nephrology who have expertise in iron/anemia. Kindly submit your comments via the feedback form on the website no later than Monday, November 11th.

Best,

Jodie

Jodie L. Babitt, M.D.
Associate Professor of Medicine
Harvard Medical School

MGH Research Scholar

Director of Translational Research

Nephrology Division
Massachusetts General Hospital
185 Cambridge St., CPZN 8208
Boston, MA 02114
tel. 617-643-3181
fax 617-643-3182
Babitt.Jodie@mgh.harvard.edu

Nobel Prize in Physiology or Medicine- Oxygen takes the stage….might iron follow?

Sir Peter Ratcliffe (Oxford University) has recently been announced as this year’s winner of the Nobel Prize in Physiology or Medicine alongside William Kaelin, Jr (Harvard University) and Gregg Semenza (Johns Hopkins University). 

This prize was awarded for seminal work describing the mechanisms of oxygen sensing and control. The discovery centers on hypoxia-inducible factors (HIFs), a family of transcription factors that orchestrate cellular responses to hypoxia, thereby triggering metabolic, angiogenic and cell-cycle adaptations. In the wider physiological context, HIFs orchestrate erythropoietic and cardiopulmonary responses to hypoxia. 

Nobel Prize Medicine 2019

Under normoxic conditions, these HIF proteins are constantly produced then targeted for proteolytic degradation by the action of prolyl hydroxylases (PHDs).  These enzymes act as oxygen sensors owing to their requirement for oxygen as a substrate. Sir Ratcliffe’s laboratory helped uncover the role of these enzymes and identified the sites at which HIFs are hydroxylated (1 , 2).

Beyond enhancing our understanding of basic homeostatic control, these discoveries have also had far-reaching translational applications, most notably that of inhibiting PHDs for the treatment of anaemia.

The interplay between oxygen and iron homeostasis has long been recognised. Sir Ratcliffe himself once declared that “HIF may as well be called iron deficiency-inducible factor”. Indeed, the PHDs that regulate HIF stability require iron as a co-factor. This is reflected in the pathophysiological manifestations of iron deficiency, that often mimic the body’s response to hypoxia, e.g. pulmonary arterial hypertension. Another important aspect of this interplay is the control of renal HIF2 by Iron Regulatory Proteins (IRPs), a mechanism that is thought to couple erythropoiesis to iron availability. 

For those reasons, this Nobel prize is good news for those of us interested in iron. Over the coming years, we are likely to learn of further intersections between iron and oxygen homeostasis. The challenge will be to capitalise on these, so that iron-altering therapies could be harnessed to treat disorders of hypoxic signalling and vice versa. Another challenge for us in the iron community will be to raise the profile of iron research even further with a Nobel prize of our very own! 

We are extremely pleased to announce that Sir Ratcliffe will be the keynote speaker at the upcoming European Iron Club meeting in Oxford, 2-5 September 2020. (EIC2020)

Contributed by Prof Samira Lakhal-Littleton, Department of Physiology, Anatomy & Genetics
University of Oxford

Official nomenclature for HFE2 and HFE has been changed/updated

From: Dr Bryony Braschi [bbraschi@ebi.ac.uk]

Dear Researchers,

Many thanks for your feedback about our proposed nomenclature update for the gene currently approved as HFE2. All researchers were supportive of a symbol update to HJV.

Some researchers asked why we have added “BMP co-receptor” to the name.
This to maintain a link between this gene, which is aliased as RGMC, and its paralogs RGMA (repulsive guidance molecule BMP co-receptor a) and RGMB (repulsive guidance molecule BMP co-receptor b). It is a small amount of additional functional information that may be useful to researchers that are not associated with the field that visit our gene reports. It may be that most researchers in the field will choose to refer simply to HJV (hemojuvelin) in their publications.

Therefore the new nomenclature for this gene in human and its orthologs across vertebrates will be:

GENE SYMBOL: HJV
GENE NAME:   hemojuvelin BMP co-receptor
SYNONYMS:    HFE2, JH, HFE2A, RGMC, HJV, haemojuvelin

We hope you approve of this update and will use, or at least mention the new nomenclature in your future publications.

We would also like to propose a name only update for the gene currently approved as HFE (hemochromatosis). As you may know, the remit of the HGNC has expanded to naming the orthologs of human genes across vertebrates. Therefore, we are very keen to avoid the use of human phenotypes in gene nomenclature wherever possible as they may not be relevant across species. We will of course retain the well used HFE symbol for this gene (HGNC:4886) and the term “hemochromatosis” can of course still be used to refer to the phenotype and will remain in the gene record as a previous name, appearing on the gene symbol report on our site (www.genenames.org).

We therefore plan to make the following nomenclature update for this gene in human and its orthologs across vertebrates:

GENE SYMBOL: HFE
GENE NAME:   homeostatic regulator of iron
SYNONYMS:    HLA-H

We intend to go ahead with this, but if you have any serious objections to this then let us know. Please note that if we do not hear from you within the next 14 days then we may assume you approve of this proposal and the nomenclature may be updated as above. Thank you.

Best wishes,
Bryony

Bryony Braschi, PhD
Gene Nomenclature Advisor
HUGO Gene Nomenclature Committee (HGNC)
European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Genome Campus Hinxton, Cambridgeshire
CB10 1SD, UK
phone: +44 (0)1223 494332
fax:   +44 (0)1223 494468