Category Archives: Jobs

Postdoctoral Research Fellow in Iron Biology – IRSD Toulouse, France

A postdoctoral research fellow position is available for 3 years in the Delphine Meynard research group (http://en.irsd.fr/team-4-genetics-and-regulation-of-iron-metabolism.html).  We are part of the Digestive Health Research Institute (IRSD) in Toulouse in France. Toulouse is a dynamic research area located in south of France that comprises many internationally recognized laboratories and gives access to a network of high-level skills research platforms in life sciences (fundamental biology, agronomy, environment, health) making possible almost all research projects.

The Digestive Health Research Institute accredited by INSERM, INRA, ENVT and Toulouse University, is internationally recognized and offerins a productive scientific environment centered on basic and clinical research to understand and treat diseases of the intestine and the liver. IRSD brings together a total of >80 researchers, professors, technicians, students and post-docs of different nationalities.

Our research focuses on iron metabolism and its disturbance in human diseases. Our lab is a dynamic team of scientists, MD, graduate students, and technicians. Our main goal is to characterize the regulation of iron homeostasis at the cellular and molecular levels and to develop new therapeutic strategies for the treatment of iron related disorders. The postdoctoral project will specifically address the role of proteases in the regulation of iron homeostasis and develop new strategies to target those proteases. The postdoctoral fellow will use several approaches including molecular and cellular biology, animal models, and biochemistry but also techniques related to proteases such as enzymatic activity assay, activity based probes, and in situ zymography.

Applicants for this position must have a Ph.D. in the biochemical sciences. A suitable candidate will have a proven track record of research accomplishments including first author publications in international peer-reviewed journals and excellent experience in: molecular and cellular biology, biochemistry, mouse models. Skills with proteases would be appreciable. In addition, excellent communication/interpersonal skills are required.

Please email a cover letter, CV, and two letters of support from former mentors or collaborators (including their contact information) to Delphine Meynard: delphine.meynard@inserm.fr

Postdoctoral Research Fellow in Iron Biology, New York Blood Center (NYBC, New York, NY)

A postdoctoral research fellow position is available in the Vinchi Laboratory at the New York Blood Center. We are currently seeking PostDoc candidates to investigate mechanisms of heme/iron-driven inflammation and oxidative stress within the Iron Research Program of the institute. We are part of the Lindsley F. Kimball Research Institute, the research branch of the New York Blood Center, one of the most comprehensive blood centers in the world. NYBC focus is on cultivating excellence by merging cutting-edge innovation with diligent customer service, groundbreaking research, and comprehensive program and service development. The main goal of the Iron Program is to investigate the impact of iron overload and deficiency on the pathogenesis of human diseases, including sickle cell disease, cardiovascular disease and cancer. Our research investigates the molecular mechanisms of heme/iron-driven inflammation, oxidative stress and vascular dysfunction, and the role of detoxification systems in counteracting these effects. The candidate will perform cutting-edge research that integrates human biology and hematology with novel therapies using innovative technologies and approaches including classic molecular, cellular, and biochemical techniques, as well as modern imaging, sequencing and single cell analysis techniques, bioinformatics, and preclinical in vitro and in vivo models.  In addition, he/she will collaborate with other research scientists across the NYBC, including basic and translational investigators.

Requirements include:

  • D. and/or M.D. degree in the biomedical sciences
  • A good record of high impact publications and a strong scholarly record
  • An experimental background in molecular and cellular biology (research experience with mouse models is required)
  • Ability to work independently and within a strong team environment; to identify problems in a timely manner, evaluate options and implement solutions; trong attention to detail in all work processes
  • Participation in team meetings and contribution to experimental design

 

For immediate consideration, please submit an application to Dr. Francesca Vinchi, Head of Iron Research Program (FVinchi@nybc.org),  including:

  • a full CV, including a list of publications
  • a motivational letter concisely describing your past research experience, your research interests and why you are applying
  • two letters of recommendation by referees (including their contact information)

 

To learn more about the Iron Research Program and the NYBC visit:

https://nybloodcenter.org/lindsley-f-kimball-research-institute/investigators/francesca-vinchi-phd/

www.nybloodcenter.org

 

Post – BioIron Forum November 2018 (Word)

The Institute of Research in Digestive Health (IRSD) is inviting applications for group leader positions

IRSD is a new very active Institute with interests in fundamental and translational research in the field of physiopathology of the digestive tract For details : http://en.irsd.fr/

The Institute brings together 80 scientists and supporting staff within a single research structure composed of 5 research teams with international visibility. Our Institute is worldly recognized for his work on inflammatory bowel diseases, motility disorders, neurogastroenterology, dysregulation of iron metabolism, dysfunction of the intestinal barrier, microbiota, and mucosal immunity.

IRSD is affiliated to INSERM, INRA, the National Veterinary School and the University of Toulouse. The Institute is located inside the Purpan Hospital in Toulouse and has access to excellent core facilities with highly qualified staff for flow cytometry and cell sorting, cell imaging and histology. There are also large EOPS mouse housing facilities on site, with L2 facilities for infectious models.

In order to reinforce its research capacity, IRSD is looking for new junior group leaders addressing basic, clinical or translational research questions related to the physiopathology of digestive with, if possible, a special interest for epigenetic regulations.

Young scientists of any nationality, at junior or midcareer level, and with a good track record of publications in internationally recognized journals, are encouraged to apply. Candidates are expected to establish independent national and international research projects and should have the qualifications to apply for ATIP/AVENIR (270 K€/3 ans) or ERC grants. They will receive a strong support from the IRSD to obtain tenured positions at INSERM or CNRS.

More information on the Institute are available on the IRSD web site http://en.irsd.fr/

Applications should be submitted to nathalie.vergnolle@inserm.fr and must include:

– a full CV, including a list of publications

– past and current research interests

– future research proposals

– letters of recommendation by referees (should be submitted with the application).

Postdoctoral Research Fellow in Iron Biology, Massachusetts General Hospital and Harvard Medical School

A postdoctoral research fellow position is available in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School. We are part of the MGH Division of Nephrology, Program in Membrane Biology, and Center for Systems Biology located in the Simches Research Center adjacent to the MGH main campus in Boston. The overarching goal of our research program is to understand the molecular and cellular mechanisms involved in iron homeostasis and to develop new therapeutic strategies to treat diseases related to disordered iron homeostasis. We employ a multidisciplinary approach including molecular and cell biology, biochemistry, and animal studies. Current focuses are to investigate iron sensing and hepcidin regulation in  the liver; crosstalk between iron, inflammation and fibroblast growth factor 23 and their contributions to mineral and bone disorder and cardiac complications in chronic kidney disease; and the role of iron and bone morphogenetic proteins in glucose homeostasis.

Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Successful applicants will have an experimental background in molecular and cellular biology, biochemistry, and/or genetics, a strong publication record, and excellent communication/interpersonal skills. Please email a cover letter, CV, and the names, telephone numbers, and email addresses of three references to Babitt.jodie@mgh.harvard.edu

Post-Doctoral Research Associate

BioIron Job Posting Kosman (PDF)

The kosmanlab
Dan Kosman
SUNY Distinguished Professor, Biochemistry

Funded by NINDDS to 2022

The objective of this Research Associate’s research is to examine the mechanisms by which eukaryotic cells take up and effllux the essential trace metals, iron and manganese. A specific focus is on the role of the amyloid precursor protein in modulating iron trafficking across the blood-brain barrier. These studies are carried out primarily in cultured mammalian cells, and primary cultures of capillary endothelial cells, astrocytes and neurons removed from mice and rats. In addition, the structure and function aspects of recombinant forms of proteins involved in these iron trafficking processes will be examined by biophysical (isothermal calorimetry, circular dichroism) and cell biologic approaches. This research involves a variety of methods including extensive use of molecular biologic/protein engineering techniques (recombinant DNA technology); cell culture; protein localization (indirect immunofluorescence, FRET); protein expression and purification; enzyme and various analyte assays (ELISAs); protein biophysical quantification (enzyme kinetics, isothermal calorimetry, circular dichroism); cellular metabolite (59Fe- and 54Mn-trafficking) kinetics.

The kosmanlab is located in the brand-new Jacobs School of Medicine and Biomedical Sciences of the University at Buffalo. Take a look at our new digs at http://kosmanlab.com/

We want to recruit a new Ph.D. to our group, one who has a demonstrated ability to work independently and to supervise less-experienced trainees. The successful candidate will be eligible for and qualified as a recipient of extramural fellowship support. Seeking such funds is a critical aspect of post-doctoral training.

To apply go to https://www.ubjobs.buffalo.edu/postings/14267

After you complete your application, please
contact Dr. Kosman directly at camkos@buffalo.edu

We look forward to hearing from you!