Post Doctoral Fellow at Regeneron Pharmaceuticals, Tarrytown, NY, United States

Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. The postdoctoral fellow position is for early career scientist trainees to receive a rigorous scientific training at Regeneron under the auspices of a scientist mentor for up to four years. Fellows will be expected to conduct creative exploratory research that results in publications.

The successful candidate will investigate the role of iron in the development of metabolic dysfunction. Elevated iron levels, particularly in beta-thalassemia and hereditary hemochromatosis, are associated with an elevated risk of developing type-2 diabetes, but the physiological relationship between iron and metabolic dysfunction is unknown. We generated mouse models of beta-thalassemia and hereditary hemochromatosis, both of which demonstrate impaired metabolic parameters. The postdoctoral fellow will dissect the mechanistic links between iron overload and metabolism, including assessing oxidative stress in the pancreas, glucose oxidation in skeletal muscle, and hepatic gluconeogenesis in our mouse models of disease.

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