Invitation to submit research and review articles related to Renal Iron Handling in Health and Disease.
While iron is a pre-requisite for life, it also initiates a cascade of pathological events that lead to parenchymal damage and activation of immune cells. Iron-dependent regulated cell death, namely ferroptosis, potentiates kidney injury and ironically, delivery of iron (or iron-loaded macrophages) to the kidney reduces the severity of the disease. Clearly, this represents our incomplete understanding iron metabolism in kidney health and pathology.
We invite investigators to contribute original research articles as well as review articles that will aid in the understanding of iron metabolism and trafficking in the initiation and outcomes of kidney injury and chronic kidney disease.
Potential topics include, but are not limited to:
• Characterization and determination of the role of the kidney in iron trafficking and metabolism
• Effects of disorders of systemic iron metabolism (e.g. iron deficiency and iron overload) on the kidney, including new techniques to measure iron content (free or protein-bound) in tissue, plasma and cells
– Iron homeostasis in kidney disease (proteinuria, glomerulopathy and chronic kidney disease)
• Mechanism of iron-mediated kidney injury;
• Modulation of iron and hepcidin levels as therapeutic strategies to overcome injury and/or promote recovery
Please use the following link to access the submission page