Phylogenetic origin of hepcidin

Paolo sent me this comment/question, which I thought would be great to post to the forum.

“We had a number of very interesting reviews on the function, regulation and structure of the human and mouse hepcidin, even of the camel one, but we know very little of its phylogenetic origin. For example there is a large number of papers on fish hepcidin, mostly linked to inflammation, infection, but few, if any, regarding iron homeostasis.

Briefly, is it known when first occurred the encounter between hepcidin and ferroportin with the ensuing regulatory consequences?”


Well, iron community, does anyone have any thoughts on this?